学习经历、社会兼职及获奖情况

徐金瑞，男，1975年生，博士，教授，现任金沙集团1862cc成色生命与食品学部副部长，硕士生导师，主要研究方向为病原生物学与宿主免疫。主持完成国家自然科学基金项目1项，在研国家自然科学基金项目1项，主持完成宁夏自然科学基金项目5项，在研宁夏自然科学基金项目1项。参与完成国家自然科学基金项目2项，教育部科学技术研究重点项目1项。在国内外学术期刊发表论文70余篇，其中以一作或通讯作者发表SCI论文16篇。宁夏生物分子检测学会理事，宁夏生物学会监事。承担本科生及研究生《遗传学》、《生物统计学》等课程的教学任务。先后荣获宁夏自然科学优秀学术论文一等奖1项、二等奖1项、三等奖1项，获金沙集团1862cc成色“第七届教学优秀奖”、金沙集团1862cc成色“第二届青年教师教学基本功大赛三等奖”、金沙集团1862cc成色“社会治安综合治理工作先进个人”、金沙集团1862cc成色“优秀共产党员”、学院“教学评估先进个人”、学院“优秀共产党员”。指导完成金沙集团1862cc成色大学生创新项目6项，获二等奖1项。

代表性研究成果

1.Li, Mengyuan, Yueyang Liu, Xueyi Nie, Boli Ma, Yabo Ma, Yuxin Hou, Yi Yang, Jinrui Xu^*, and Yujiong Wang^*. 2023. "S100A4 Promotes BCG-Induced Pyroptosis of Macrophages by Activating the NF-κB/NLRP3 Inflammasome Signaling Pathway" International Journal of Molecular Sciences 24, no. 16: 12709. https://doi.org/10.3390/ijms241612709

2.Nie, Xueyi, Boli Ma, Xiaotan Yuan, Mengyuan Li, Yueyang Liu, Yuxin Hou, Yi Yang, Jinrui Xu^*, and Yujiong Wang*. 2023. "Endoplasmic Reticulum Stress Mediated NLRP3 Inflammasome Activation and Pyroptosis in THP-1 Macrophages Infected with Bacillus Calmette-Guérin" International Journal of Molecular Sciences 24, no. 14: 11692. https://doi.org/10.3390/ijms241411692

3.Chen Q, Zheng X, Li Y, Ma B, Nie X, Li M, Liu Y, Xu J*, Yang Y*. Wnt5a regulates autophagy in Bacille Calmette-Guérin (BCG)-Infected pulmonary epithelial cells. Microb Pathog. 2022 Oct 13;173(Pt A):105826. doi: 10.1016/j.micpath.2022.105826. Epub ahead of print. PMID: 36243383

4.Zheng X, Li M, Chen Q, Ma B, Nie X, Liu Y, Yang Y, Xu J*, Wang Y*. Ror2-mediated cholesterol accumulation regulates autophagic activity within BCG-infected macrophages. Microb Pathog. 2022 Jun;167:105564. doi: 10.1016/j.micpath.2022.105564. Epub 2022 May 7. PMID: 35537593.

5.Ma Y, Du C, Xie X, Zhang Y, Wang C, Xu J, Xia G, Yang Y. To explore the regulatory role of Wnt/P53/Caspase3 signal in mouse ovarian development based on LFQ proteomics. J Proteomics. 2023 Feb 10;272:104772. doi: 10.1016/j.jprot.2022.104772. Epub 2022 Nov 19. PMID: 36414229.

6.Zhang Y, Xie X, Ma Y, Du C, Jiao Y, Xia G, Xu J^*, Yang Y^*. Cyproterone Acetate Mediates IRE1α Signaling Pathway to Alleviate Pyroptosis of Ovarian Granulosa Cells Induced by Hyperandrogen. Biology (Basel). 2022 Dec 4;11(12):1761. doi: 10.3390/biology11121761. PMID: 36552271; PMCID: PMC9775519.

7.Jinrui Xu, Yuquan Yang, Zhaoyuan Hou, Hao Jia*, Yujiong Wang*, TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions.Theranostics 2021, 11(15)：7379-7390.

8.Jinrui Xu, Yanbin Zhou, Yi Yang, Cuiping Lv, Xiaoming Liu, Yujiong Wang. Involvement of ABC-transporters and acyltransferase 1 in intracellular cholesterol-mediated autophagy in bovine alveolar macrophages in response to the Bacillus Calmette-Guerin (BCG) infection. BMC Immunology (2020) 21:26. https://doi.org/10.1186/s12865-020-00356-x

9.Yi Yang, Yingfei Sun, Jinrui Xu, Kangda Bao, Meihui Luo, Xiaoming Liu, Yujiong Wang. Epithelial Cells Attenuate Toll-like Receptor-mediated Inflammatory Responses in Monocyte-derived Macrophage-like Cells to Mycobacterium tuberculosis by modulating PI3K/Akt/mTOR signaling pathway. Mediators of Inflammation, Volume 2018, Article ID 3685948, 19 pages（共同一作）

10.Han Cai, Bingying Liu, Tingting Yang, Yi Yang, Jinrui Xu, Zhiqing Wei, Guangcun Deng, Gang Ning, Junxia Li, Jing Wen, Wei Liu, Zhangli Ni, Yuzhen Ma, Meijia Zhang, Bo Zhou, Guoliang Xia, Hong Ouyang, Chao Wang, Involvement of PKCε in FSH-induced connexin43 phosphorylation and oocyte maturation in mouse, Biology Open (2018) 7, bio034678. doi:10.1242/bio.034678.

11.Hao Yan, Jia Wen, Tuo Zhang, Wenying Zheng, Meina He, Kun Huang, Qirui Guo, Qian Chen, Yi Yang, Guangcun Deng, Jinrui Xu, Zhiqing Wei, Hua Zhang, Guoliang Xia , Chao Wang. Oocyte-derived E-cadherin acts as a multiple functional factor maintaining the primordial follicle pool in mice. cell death and disease. 2019 Feb 15;10(3):160

12.Xinyi Mu, Jia Wen, Qian Chen, Zhengpin Wang, Yijing Wang, Meng Guo, Yi Yang, Jinrui Xu, Zhiqing Wei, Guoliang Xia, Mengye Yang, and Chao Wang. Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice. Biology Open. 2018 Nov 12;7(11):bio035626. doi: 10.1242/bio.035626.

13.Zhiqiang Li, Jianhua Chen, Ying Zhao, Yujiong Wang, Jinrui Xu, Jue Ji, Jingyi Shen,Weiping Zhang, Zuosong Chen, Qilin Sun, Lijuan Mao, Shulin Cheng, Bo Yang, Dongtao Zhang, Yufeng Xu, Yingying Zhao, Danping Liu, Yinhuan Shen, Weijie Zhang, Changgui Li, Jiawei Shen, Yongyong Shi. Common variants in ZMIZ1 and near NGF confer risk for primary dysmenorrhoea. NATURE COMMUNICATIONS, 2017,8:14900. doi:10.1038/ncomms14900.